LEVOFLOXACIN HEMIHYDRATE PDF

Each film-coated tablet of Levofloxacin mg Film-coated Tablets contains mg of levofloxacin equivalent to mg of levofloxacin hemihydrate. Name: Levofloxacin hemihydrate; Drug Entry: Levofloxacin. A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling. Find patient medical information for Levofloxacin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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These findings were more marked in young animals. Fertility Levofloxacin caused no impairment of fertility or reproductive performance in rats.

The risk of tendinitis and tendon rupture is increased in patients aged over 60 years, in patients receiving daily doses of mg and in patients using corticosteroids. C Risk not ruled out. Other relevant information Clinical pharmacology studies have shown that the pharmacokinetics of levofloxacin were not affected to any clinically relevant extent when levofloxacin was administered together with the following drugs: With regard to more usual side effects, in pooled results from patients exposed to levofloxacin in 29 clinical trials, 4.

All patients should consult their physician if they experience symptoms of tendinitis. Levofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. J01MA12 Levofloxacin is a synthetic antibacterial agent of the fluoroquinolone class and is the S – enantiomer of the racemic active substance ofloxacin.

Levofloxacin Hemihydrate | CAS | SCBT – Santa Cruz Biotechnology

Due to the mechanism of action, there is generally no cross-resistance between levofloxacin and other classes of antibacterial agents.

A wide variety of other uncommon but serious adverse events have been associated with fluoroquinolone use, with varying degrees of evidence supporting causation.

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If superinfection occurs during therapy, appropriate measures should be taken.

Levofloxacin absorption is significantly reduced when iron salts, or magnesium- or aluminium-containing antacids, or didanosine only didanosine formulations with aluminium or magnesium containing buffering agents are administered concomitantly with levofloxacin tablets. Blood and lymphatic system disorders. Unlike ciprofloxacin, levofloxacin does not appear to deactivate the drug metabolizing enzyme CYP1A2.

Linearity Levofloxacin obeys linear pharmacokinetics over a range of 50 to mg. It most frequently bemihydrate the Achilles tendon and may lead to tendon rupture. Probenecid and cimetidine had a statistically significant effect hemlhydrate the elimination of levofloxacin.

US Food and Drug Administration. Archived PDF from the original on 11 June It is a weak inhibitor of CYP2C9[33] suggesting potential to block the breakdown of hemihydrtae and phenprocoumon. Cross-resistance between levofloxacin and other fluoroquinolones is observed.

Levofloxacin | C36H42F2N6O9 – PubChem

Levofloxacin caused no impairment of fertility or reproductive performance in rats and its only effect on leevofloxacin was delayed maturation as a result of maternal toxicity. Levofloxacin in the treatment of complicated urinary tract infections and acute pyelonephritis. Levofloxacin is not recommended in patients with a known history of myasthenia gravis.

In very rare cases these have progressed to suicidal thoughts and self-endangering behaviour- sometimes after only a single dose of levofloxacin see section 4. Tendinitis and tendon rupture, sometimes bilateral, may occur within 48 hours of starting treatment with levofloxacin and have been reported up to several months after discontinuation of treatment. Psychotic disorders with self-endangering behaviour including suicidal ideation or suicide attempt see section 4. Frequencies are defined using the following convention: Package inserts mention that levofloxacin is to be avoided in patients with a known hypersensitivity to levofloxacin or other quinolone drugs.

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Creating an account with us makes your shopping experience hemihdyrate easier and faster. If vision becomes impaired or any effects on the eyes are experienced, an eye specialist should be consulted immediately see sections 4.

Levofloxacin

Angioedema Hypersensitivity see section 4. CDAD may range in severity from mild to life threatening, the most severe form of which is pseudomembranous colitis see section 4. Archived from the original on 25 February Marketing authorisation number s 9. Create an account quickly and easily with hemihhydrate preferred social network account. This site uses cookies. Create a new account. Non-species related breakpoints 4. Levofloxacin is contraindicated in patients with a history of epilepsy see section 4.

The ldvofloxacin given below is based on data hemihydrage clinical studies in more than patients and on extensive post marketing experience. Breakpoints apply to an oral dose of mg x 1 to mg x 2 and an intravenous dose of mg x 1 to mg x 2.

Levofloxacin mg Film-coated Tablets is indicated in adults for the treatment of the following infections see sections 4.

Diarrhoea — haemorrhagic which in very rare cases may be indicative of levofloxacun, including pseudomembranous colitis see section 4. Levofloxacin is stereochemically stable and does not undergo chiral inversion. Levofloxacin is metabolised to a very small extent, the metabolites being desmethyl-levofloxacin and levofloxacin N-oxide. Similar results have been reported when levofloxacin is taken with iron supplements and multi-vitamins containing zinc.

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