A.I.VOGEL PREPARATYKA ORGANICZNA PDF

A. I. Vogel, Preparatyka organiczna (WNT Warszawa,), p. Zielińska J., Makowski M., Maj K., Liwo A., Chmurzyński L.() Anal. A.I. Vogel. Preparatyka Organiczna, WNT, Warszawa (), p. F.V. Lovecchio, E.S. Gore, D.H. Bush. J. Am. Chem. Soc., 96 (), p. Soc. (), p. A.I. Vogel. Preparatyka Organiczna W.N.T. Warszawa ( ), p. C.G. Hatchard, C.A. Parker. Proc. Roy. Soc., A (), p.

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The aqueous layer was extracted with additional dichloromethane mLand the combined organic layers were washed with water 50 mL and brine 50 mL. Compound 34 was prepared using the general procedure described above with respect to compound 14, but, 4-fluoroaniline was substituted for aniline in step A, 2-tert-butoxycarbonylamino-propionic acid 2,5-dioxopyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, the alternate procedure TFA deprotection was used in step C, and 2-fluorochloropurine was substituted for 6-bromopurine in step D.

In some embodiments, the compound of formula I or a salt thereof is crystallized from one or more solvents selected from the group comprising water, ethanol, methanol, isopropanol, n-propanol and acetone. Aliquots 8 mL of heparinized blood from healthy volunteers are layered on 3 mL cushions of 7.

For tissue or cellular administration, penetrants appropriate to the particular barrier to be permeated are used in the formulation. For example, ethanol and acetyl chloride may be used to generate HCl in situ.

In some embodiments, n is 1, 2, or 3; and each R 5 is independently selected from a group consisting of methyl, F, and Cl. Compound 27 is shown below. Levels of phosphatidylinositol-3,4,5-triphosphate PIP3the primary product of PI 3-kinase activation, increase upon treatment of cells with a variety of agonists. The protein profile of the enzyme complex during heparin chromatography corresponded to that of lipid kinase activity. Compound was prepared using the general procedure described above with respect to compound 14, but 2-amino-4,5-difluoro-benzoic acid was substituted for 2-aminomethyl-benzoic acid in step A, 2-tert-butoxycarbonylamino-propionic acid 2,5-dioxopyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, and the alternate procedure TFA deprotection was used in step C.

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Preparatyka organiczna vogel pdf download

The process of claim 18wherein step a further comprises a step of combining a base selected from the group consisting of pyridine, 4-dimethylaminopyridine, triethylamine, isopropylethylamine, imidazole, DABCO, Prepratyka, 2,6-lutidine, and N,N-diisopropylethylamine.

The process of claim 2wherein the compound prepsratyka formula 14 or a salt thereof is crystallized from one or more solvents selected a.i.vlgel the group consisting of ethanol, isopropanol, n-propanol, methanol, and water. In some embodiments, removal of the THP protective group proceeds to completion or near completion in the absence of water.

For preparations comprising proteins, the formulation can include stabilizing materials, such as polyols e. GB, vogel – Preparatyka organiczna. In some embodiments, the compound of formula a.i.vogep or a salt thereof is crystallized from one or more solvents selected from the group consisting of alcohol and water.

The process of claim 1wherein step a further comprises a base selected from the group consisting of pyridine, 4-dimethylaminopyridine, triethylamine, isopropylethylamine, imidazole, DABCO, DBU, 2,6-lutidine, and N,N-diisopropylethylamine. Also included in this definition are ammonium and substituted or quaternized ammonium salts.

Compound 47 was prepared using the general procedure described above with respect to compound 14, but 2-aminofluoro-benzoic acid was substituted for 2-aminomethyl-benzoic acid in step A, 2-tert-butoxycarbonylamino-propionic acid 2,5-dioxopyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, the alternate procedure Ai.vogel deprotection was used in step C, and 2-aminobromopurine was substituted for 6-bromopurine in step D.

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The process of claim 2wherein step c is performed at a temperature between 0 and 70 degrees Celsius. US USB2 en Office Action mailed Mar. After cooling, the reaction was purified by flash chromatography to provide the quinazolinone 16 as a pale yellow solid. Inflammation can result from infection with pathogenic organisms and viruses, and prepatatyka noninfectious means such as trauma or reperfusion following myocardial infarction or stroke, immune response to foreign antigen, and autoimmune responses.

Compound 69 is shown below. S tert-butoxycarbonyl amino propanoic acid. Compound 18 was prepared using the general procedure described above with respect to compound 14, but 2-fluorochloropurine was used in place of 6-bromopurine in step D.

Compound 47 is preparatka below. New heterocyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them. After washing three times with phosphate buffered saline containing 0.

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In some embodiments, the process further comprises synthesizing a compound of formula Compound 55 was prepared using the general procedure described above with respect to compound 54, but preparagyka 50 was substituted for compound International Search Report mailed Apr.

Among the mammalian animals that can organicczna treated are, for example, humans; companion animals petsincluding dogs and cats; farm animals, including cattle, horses, sheep, pigs, and goats; laboratory animals, including rats, mice, rabbits, guinea pigs, and nonhuman primates; and zoo specimens.

This application claims the benefit of and priority to U. Process for preparing phosphatidylinositol 3-kinase organczna and intermediates thereof. Free p85 subunit was removed from the column during the washing step and only the heterodimeric enzyme complex eluted at mM imidazole.

The process of claim 2wherein step e comprises an acid a.i.vogl from the group consisting of a mineral acid, TFA and a Lewis acid. Excess stain is washed and the pit depths are quantitated using confocal microscopy. In certain embodiments, compounds of formula 8151419 organicna, 20and 21are disclosed. The starting material includes any of the starting or intermediate compounds disclosed herein, a salt thereof, or a reagent.

In further embodiments, R 3 is an amino protective group and R 4 is a purinyl group. The syrup was dissolved in dichloromethane mL and was slowly added to a solution of N—BOC-Laminobutyric acid g, 0. Knight and Shokat, Chemistry and Biology Compound 81 was prepared using the general procedure described above with respect to compound 80, but 2-aminobromopurine was substituted for 6-bromopurine in step D. A mL, one-neck, round bottomed flask equipped with a magnetic stirrer was purged with nitrogen, and then charged with the compound mg, 0.

Compound 92 was prepared by adding trifluoroacetic acid to a solution of 2-[2-tert-butoxy 9H-purinylamino -ethyl]phenyl-3H-quinazolinone in dichloromethane. Other compounds or radicals may be named with common names, or systematic or non-systematic names.