PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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The tissue damage then provokes inflammatory response by the actifity of mediators and chemotactic factors 4. Wiley Series Chemistry and Pharmacology of Drugs. The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant. A herbarium specimen of this plant has been deposited at Principal K.

Anti Inflammatory Activity The activity was evaluated by using carrageenan induced paw edema in rats. Protective activity of some indigenous medicinal plants on gastric ulceration in albino rats. Hence, reduction of oxidative stress produced by VN might possibly be due to these chemical constituents. The carrageenan-induced paw edema in rats is believed to be biphasic. This is because of the adverse effects associated with synthetic drugs.

Lipid peroxidation is achivity for damaging cell membranes thereby further intensifying inflammatory damage. The animals were fasted overnight prior to the actual experimental procedure.

The prevention of oxidative damage to tissue could therefore be one of the mechanisms responsible for the antiinflammatory effect shown by the plant.


Flavonoids are an important group of polyphenols and are reported to inhibit prostaglandin synthesis, which are known mediators of inflammation Please leave a message, we will get back you shortly.

CDepartment of Biochemistry, for allowing us to perform bio-chemical investigation in the department. These findings were in agreement with the findings of Telang et al. S Sevagram WardhaMaharashtra for providing departmental facilities.

Pergamon Press, New York, pp: Ascorbic acid protects lipid in human plasma and low density lipoprotein against oxidative damage.

Please review our privacy policy. Indian Council of Medical Research India 2: The toxicity study also revealed its safeness, thus the plant can be hypothesized it is nontoxic. DX 7 days orally in cotton inflammafory granuloma test as standard controls, respectively.

D I Toxicant control Carrageenan 0. When onflammatory was evaluated for its antioxidant activity by studying its lipid peroxidation inhibitory activity; it exhibited a concentration dependent inhibition of formation of thiobarbituric acid reacting substances Table 1 with a potent antioxidant activity.

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Each response was recorded for 30 sec. The anti-inflammatory activity was studied by using carrageenan induced paw edema in rats.

The plant was collected from local area of Sevagram in the month of June, X 7 days, p. Academic press, New York and London Gum acacia, phosphoric acid, potassium ferricyanide, ferric chloride were of LR grade and obtained from local infflammatory. The filtrates were kept on water bath to obtain the crude extract [ 10 ]. Gandevi GujaratIndia, Tel: Cycloxygenase 1 and 2.

Albino rates of either sex weighing pf were procured from Animal House of Kota College of Pharmacy, Kota, Rajasthan, and were selected in the study. The difference in wet and dry weights of granuloma from control group to that of treated group indicates the anti-inflammatory activity. Albino mice of either sex, weighing gm were used to determine the lethal dose. The parameter observed and recorded was changed in behavioral, neurologic and autonomic responses.


Dose selection of test drug was based on previously reported studies Telang et al. X 7 days orally and Ibuprofen mg kg -1 B. infla,matory

Antioxidant and Antiinflammatory Activity of Vitex negundo.

The fresh leaves of VN were cleaned of extraneous matter, shade dried and powdered. Oxidative damage and pathogenesis. Antioxidant functions of carotenoids. Animals were observed for clinical signs and mortality, continuously for first 2 h.

Edema in one of the paws of the rat was induced by injecting into plantar aponeurosis 0. It belongs to the family Rutaceae [ 2 ].

The extract was concentrated under vacuum. Flavonoids as activitu evaluated by in vitro and in situ liver chemiluminescence. Oxytocin Sandoz and oestradiol valerate Sigma organon were also used for the present study.

Carrageenan-induced paw edema being an in-vivo investigational model for acute inflammation which been extensively used to determine the anti-inflammatory effect of new investigational agents. We are extremely thankful to Dr. Abstract Reactive oxygen species are actifity in various inflammatory disorders. Okuma, Steiner M, Baldini M.