Among the ameloblastomas, the desmoplastic variation is rare. The desmoplastic ameloblastoma (DA) is characterized by specific clinical, imaging, and. Desmoplastic ameloblastoma (DA) is a rare variant of ameloblastoma, and less than patients have been reported in the literature. The present case. Desmoplastic Ameloblastoma is a rare variant of ameloblastoma. 90 cases of desmoplastic ameloblastoma have been reported so far in literature. We are.

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Its aggressive nature might be due to its potential to grow to a large size; the fact that it commonly arises in the maxilla, leading to the early invasion of adjacent structures; its diffuse radiographic appearance; and the frequent histological detection of bone invasion [ 26 ]. A panoramic radiograph and computed tomography showed visible new bone formation at two years after surgery and revealed no evidence of recurrence.

Desmoplastic Ameloblastoma: A Case Report

Related articles Desmoplastic ameloblastoma. The lower border of the mandible was preserved so that the aesthetic and functional work-up could be done [ Figure 5 ].

Pathology of the desmoplastic ameloblastoma. Hybrid ameloblastoma – An unusual combination of desmoplastic and conventional ameloblastoma.

Desmoplastic Ameloblastoma: A Case Report

This report is an attempt to help the dental community in developing familiarity with the clinical presentation and at the same time advocating to develop a high index of suspicion in desmopkastic such cases.

Palatal extension Click here to view. Proper diagnosis is necessary to report such a case, so that the actual incidence can be noted. The desmoplastuc case deserves special importance be-cause of its unfamiliar appearance, potentially aggressive nature and high chances of misdiagnosis. New author database being installed, click here for details. Journal of Investigative and Clinical Dentistry.

An incisional biopsy was conducted, and the lesion was diagnosed as a benign odontogenic tumor data not shown. Odontogenic epithelial islands composed of: Ameloblastomas are common benign neoplasms that frequently arise in the molar and ramus regions of the mandible.


This is in contrast to the location of the unicystic or classic types of ameloblastoma, which usually are found in the posterior area of the mandible. None, Conflict of Interest: This article has been cited by 1 Clinicopathological characteristics of desmoplastic ameloblastoma: The unique radiographic picture seen is thought to be due to its infiltrative nature.

Usually asymptomatic and can be found incidentally on routine dental examinations Can also present as a painless swelling or expansion of jaw Pain and paresthesia are uncommon Slow growing, rarely metastasizes to lungs or CNS Metastases associated with tumor of long duration, multiple surgical procedures, radiation therapy Associated with nevoid basal cell carcinoma Gorlin syndrome Fam Cancer ; A case of peripheral DA has also been reported recently.

The patient had noticed the swelling 5 months back, which had slowly increased to the present size. The postoperative course was uneventful and examination of the patient after 1 year showed no evidence of recurrence of the lesion. No lymphadenopathies or fistulae were present. With limited understanding of its biologic behavior and prognosis, the proper treatment strategies for desmoplastic ameloblastoma are not entirely defined so far.

Related articles Adenoid odontogenic tumor ameloblastoma desmoplastic ameloblastoma maxilla. Conclusion The desmoplastic ameloblastoma is characterized by specific clinical, imaging, and histological features.

This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Various immunohistochemical studies have reported DA tumor cells as showing variable expression of S protein and desmin, high expression of caspase-3 and Fas, decreased expression of cytokeratin 19 and high expression of p Histological features consisted of proliferating, irregularly shaped islands and cords of odontogenic epithelium of varying sizes embedded in a desmoplastic connective tissue stroma.

Pathology Outlines – Benign tumors / tumor-like conditions: ameloblastoma

Therefore, block excision is the most widely used treatment to avoid recurrence. The lesion was treated via enucleation and curettage of the marginal bone and fenestration. Histologically, DA is characterized by the presence of extensive stromal collagenization or desmoplasia containing small nests and strands of odontogenic epithelial tissue [ 2 — 6 ].


Pathology of the desmoplastic ameloblastoma. Home About Us Advertise Amazon. Please review our privacy policy. Desmoplastic ameloblastoma in the maxilla: Related articles Desmoplastic ameloblastoma odontogenic tumor stromal desmoplasia. Desmoplastic ameloblastomas of he mandible: The islands consisted of peripheral cuboidal cells and central spindle cells.

J Oral Pathol Med ; Intraoral amrloblastoma radiograph shows an ill-defined multilocular lesion with loss of periodontal ligament space and displacement of lateral incisor a ; maxillary occlusal radiograph showing multilocular appearance and buccal cortical expansion b.

Occlusal radiograph of the mandible Click here to view. Benign neoplasm’s and tumor-like lesions arising from the odontogenic apparatus showing odontogenic epithelium with mature fibrous stroma, without ectomesenchyme; p. A panoramic radiograph showing a well-defined large radiolucent lesion in the right mandible.

Approximately half of the desmoplastic lesions are located in the maxilla, and the vast majority of them occur in the anterior or premolar portion of the jaws. The radiographic features of DA also differ from the conventional ameloblastoma.

A year-old male patient presented to our hospital with a complaint of swelling in the right lower premolar region Figure 1. Reconstruction with free fibula flap Cervelli, D. In all the reported cases of desmoplastic ameloblastomas, typical radiographic features of ameloblastoma were not observed. Please review our privacy policy. Desmoplastic ameloblastoma is a relatively rare variety of ameloblastoma and only very few cases have been reported so far.