Diazotization Titration or Nitrite Titration. Diazotization is used in the analysis of aromatic compounds containing an amino group in the. View Notes – from ECH at University of Florida. Diazotization titration (Nitrite Titration) Mr. V. M. Patil Assistant Professor & PG. Quantitative estimation of Eflornithine by Nitrite (Diazotization) titration Here the amino group of Eflornithine is diazotized with sodium nitrite solution in.
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The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt. This diazonium ion is stabilized by the displacement of the positive charge at the ortho and para positions of the ring. Then the electrodes are connected to the potentiometer and slowly titrated with sodium nitrite solution until a permanent deflection is observed at the end point.
To make this website work, we log user data and share it with processors. Unknown 5 October at Used in the determination of the chloropheneramine. Appropriately weighed sodium nitrite is dissolved in the water and made up to the desired volume. Hence the non-aqueous titrimetric method is used. Labels Diazotization Titrations free pharmacy study material pharmaceutical analysis pharmaceutical analysis lecture notes. There are mainly three types of methods based on the titration procedure.
4. Diazotization Titrations – Pharmaceutical Analysis [Book]
Sulphanilic acid and anthranilic acid. This is prepared by immersing the filter paper in the starch mucilage and potassium iodide solution. Diazotizxtion Electrodes Potentiometric electrodes measure: Classified as solid state, heterogeneous, liquid ion exchanger and glass type.
Chapter 3 Chemical reactions. The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt. The excess of nitrous acid is removed by the addition of ammonium sulphamate solution. The main principle involved in this method is the formation of the diazo oxide which is more stable than the diazo compounds.
The end point is determined by streaking one drop of the titration solution on the starch iodide paper until blue colour is appeared.
A Seminar on Potentiometric and Diazotization Titrations
Feedback Privacy Policy Feedback. Tiitration amine reacts with the nitrous acid to form tittration, which is followed by the tautomerisation and the water molecule is lost to form the diazonium ion. The liberated iodine is back titrated with the sodium thiosulphate using starch as the external indicator.
This resulting solution is known as the standard solution. Used in the determination of the dopamine. Addition of sodium nitrite to the sample solution takes time to react with the amino group present in the sample solution. Start Free Trial No credit card required. About project SlidePlayer Terms of Service.
The diazonium salts formed are not stable at elevated temperatures.
Volumetric or titrimetric analysis are among the most useful and accurate analytical techniques, especially. After diazotization, one drop of the resulting solution is placed on the starch iodide paper which changes into dark colour.
A Seminar on Potentiometric and Diazotization Titrations – ppt video online download
The reaction mechanism was first proposed by Peter Griessin. Reaction time it takes 10—15 min: What are the advantages of diazotization titrimetry? This information is too useful and my request to you that give some information about errors chapter. Thus the electrode will act as if it were an electrode of metallic hydrogen.
Diszotization next method for the detection of the end point in the diazotization titration is by adding the potassium iodide to the nitrous acid with excess acid which liberates the iodine. What is a chemical reaction? Used in the determination of the amphetamine. Volumetric Analysis Volumetric analysis is when the volume of a reactant required to complete a chemical reaction is measured.
They are as follows: Auth with social network: Equivalence point is indicated by a marked deflection in the titration curve. The main diazotjzation …. The steps involved in the non-aqueous titrimetric method are proposed by the Tomicek.
The following conditions are required for the diazotization titration of the amino group containing samples. The percentage amount of the sulpha drug is determined by the following equation: The general procedure is followed by weighing the sample and transferring it into the standard flask.
The end point is detected by the formation of the blue colour with starch iodide paper. The end point detection is very difficult.
Stay ahead with the world’s most comprehensive technology and business learning platform. These are extremely weak and cannot be analysed using normal titrimetric methods. The obtained nitrous acid is reacted with the primary aromatic amine to form the diazonium salt.