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It was found that the synthesis of 4-hydroxyquinolones proceeds best when an electron-donor group R is substituent in aniline. Oikawa, Biosynthetic studies on the antibiotics PF Kedinjenja, A simple and convient synthesis of 4,6-disubstituted 3-cyanopyridin-2 1H -ones under solvent-free microwave conditions, Indian J.
Almqvist, Pilicides–small molecules targeting bacterial virulence, Org. The reaction was performed in 1,2-dichlorobenzene, in which the reactants are soluble, but the product of the reaction is not.
It was demonstrated that the sulfur in the pilicide scaffold could be exchanged for oxygen with an almost retained pilicide activity. TFA was used as a proton source reducing the formation of byproducts and increasing the isolated yields.
The optically active bicyclopyridone was obtained by the reaction of acyl-ketenes with substituted [[DELTA]. Different combinations of fragments were used: This synthesis is given heterociklicn Figure 2. The obtained enaminones, without purification, react with different methylene nitriles at [degrees]C for 5 min in 2-propanol and in the presence of a catalytic amount of piperidine base.
It has antioxidant properties and is used in the treatment of hyperglycemia . Uscumlic, Synthesis, structure and solvatochromic hetdrociklicna of 3-cyano-4,6-diphenyl 3and 4-substituted phenylazo pyridones, J. Valentic, Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 5-substitutedmethylcyanohydroxypyridones, J.
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Separate each e-mail address with a semicolon Subject line: Microwave synthesis is among methods that respect the principles of the so-called “green chemistry” which is one more reason for performing this type of synthesis . Besides the conventional synthesis, microwave assisted syntheses were also developed. Part IV Influence of 3-alkyl-2,4-pentanedione and Heterkciklicna cyanoacetamide structure on the enzyme catalyzed synthesis of substituted 3-cyanopyridones, Indian J.
On the other hand, microwave irradiation is an efficient way of heating where energy is transmitted directly through interaction with polar molecules present in the reaction mixture [40,41]. US US A new look at mesogenic 4-pyridones, Liquid Cryst.
The authors would like to thank the Ministry of Education, Science and Technological Development of the Republic of Serbia for the financial support project jerinjenja MijinJelena M. In the beginning, the synthesis was performed using conventional microwave ovens.
Microwave synthesis requires less acid which results in milder reaction conditions. Synthesis of other ring fused 2-pyridone derivatives In the last part of this review, the synthesis of condensed derivatives of 2-pyridone ring fused N-substituted 2-pyridones will be presented.
A good example of such a combination is given in a paper by Gorobets et al. Kappe, Controlled microwave heating in modern organic synthesis, Angew. A general procedure for obtaining substituted 2-pyridones is the Guareschi-Thorpe condensation reaction of 1.
Heterociklično jedinjenje — Википедија, слободна енциклопедија
Misic-Vukovic, Synthesis of substituted 3-cyanopyridones: Jovancic, Synthesis, properties and colour assessment of some new heteroci,licna 3- and 4-substituted phenylazo -4,6-dimethylcyanopyridones, J. Nasuprot tome, mikrotalasno zracenje je efikasan izvor zagrevanja koji direktno prenosi energiju kroz interakciju sa polarnim molekulima prisutnim u reakcionoj smesi.
The presence of [R. Due to increased product yields and purity, lower waste and sometimes solvent free conditions, microwave assisted syntheses are among the methods that respect the principles of the “green chemistry”. First, we will discuss the microwave synthesis of 2-pyridones. Synthesis of 2-pyridone based bifunctional compounds 1,4-dihydropyridines by the condensation of dialdehyde, Meldrum’s acid, heterocklicna acid and ammonium acetate is another example of type condensation of pyridones Figure 11 .
Condensed 2-pyridone derivatives can also be obtained from heterociklocna obtained from dimethylformamide diethyl acetal DMFDEA and CH-acidic carbonyl compounds.